Definition: Temozolomide is an "alkylating agent" that links specific sections of DNA, thus preventing cell division and in turn, killing the cell. It is only FDA approved to treat brain cancer but it is also used "off label" in patients with melanoma that has metastasized (spread) to the brain or nervous system. Although recent research has shown that temozolomide has a slightly higher response rate than the related chemotherapy drug dacarbazine, it didn’t improve the statistic that really counts: overall survival. However, since temozolomide comes in convenient pill form, some doctors prescribe it for patients who have difficulty with IV infusions or are unable to travel to a healthcare facility for the equally effective dacarbazine injection. (More details about side effects are also available.)
Also Known As: Temodar, Temodal
Common Misspellings: temozolimide
